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<div dir="ltr" data-setdir="false">Thanks, Jerry for the updated information.</div><div dir="ltr" data-setdir="false"><br></div><div dir="ltr" data-setdir="false">-- Bob Primak</div><div dir="ltr" data-setdir="false"><br></div><div><br></div>
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On Friday, April 8, 2022, 08:46:08 AM EDT, Jerome Slate <slatemd@comcast.net> wrote:
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Dear Group,<br clear="none">
The question was raised as to why the cholera epidemics in Europe
ended and why it has persisted in Haiti. A brackish water source is
the environmental reservoir. It comes out of this from time to time
and colonizes fresh water where it is not well-suited to survive. A
subsequent epidemic can be an entirely new event. <br clear="none">
A longer discussion is below:<br clear="none">
Jerry<br clear="none">
<br clear="none">
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<p class="yiv2083492290MsoNormal"><font face="Cambria"><em><span style="color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">V. cholerae</span></em><span style="color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;"><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> is a natural inhabitant of
brackish riverine
(situated on a river or riverbank), estuarine, and coastal
waters, and only a
subset of strains are known to be pathogenic to humans.</span>
Recent studies
have begun to uncover a very complex network of relationships
between </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> and other sea dwellers, and the mechanisms
associated
with the occurrence of seasonal epidemics in regions where
cholera is endemic
are beginning to be elucidated.</span></font></p>
<p class="yiv2083492290MsoNormal"><span style="">
</span></p>
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<br clear="ALL" style="">
<p class="yiv2083492290MsoNormal"><a rel="nofollow noopener noreferrer" shape="rect" name="_GoBack"></a><span style="font-size:15.0pt;color:#212121;background:white;"> </span></p>
<p class="yiv2083492290MsoNormal"><span style="font-size:15.0pt;color:#212121;background:white;"> </span></p>
<p class="yiv2083492290MsoNormal"><font face="Cambria"><span style="font-size:10pt;color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">There are numerous factors that affect <i style="">V. Cholerae </i>persistence,
survival, and
pathogenic potential. Several physicochemical conditions
affect </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> populations in the natural environment,
such as water
temperature, salinity, oxygen tension, sunlight, rainfall, pH,
and the
availability of trace elements and chemical nutrients.
Although there are
strong correlations between the changes in the physicochemical
conditions in
the environment of </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;">, the mechanisms by which some of them
affect the population
dynamics of </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> remain unknown.</span></font></p>
<font face="Cambria">
</font>
<p class="yiv2083492290MsoNormal"><font face="Cambria"><span style="font-size:10pt;color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">The known environmental hosts of </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> include algae, shellfish, chironomid egg
masses, fish,
waterfowl, amebae, and most ubiquitously, copepods </span>(small
crustaceans).</font></p>
<font face="Cambria">
</font>
<p class="yiv2083492290MsoNormal"><font face="Cambria"><b style=""><span style="font-size:10pt;color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">Human Epidemics</span></b></font></p>
<font face="Cambria">
</font>
<p class="yiv2083492290MsoNormal"><font face="Cambria"><span style="font-size:10pt;color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">Due to their low initial concentrations of
choleragenic </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;">, human carriers can show no symptoms of the
disease. </span> In
the early epidemic period, a similar process happens; this time
the patients
will show symptoms of cholera and will shed strongly adapted and
highly
virulent epidemic clones. </font></p>
<font face="Cambria">
</font>
<p class="yiv2083492290MsoNormal"><font face="Cambria"><span style="font-size:10pt;color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">It is thought that when the number of predators
of </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> significantly outnumbers the total of
toxigenic clones,
epidemics come to a collapse. For example, an increase in the
number of
bacteriophages that thrive on </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> in both water and stools is directly
correlated with
the termination of cholera epidemics.</span></font></p>
<font face="Cambria">
</font>
<p class="yiv2083492290MsoNormal"><font face="Cambria"><span style="font-size:10pt;color:rgb(33, 33, 33);background:white none repeat scroll 0% 0%;">Nonetheless, other environmental factors likely
also play a role in the self-limiting nature of cholera
epidemics</span>.<span style=""> </span>In
its natural environment <em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;"> encounters two main predators:
bacteriophages and
protozoa. It has also been found that some antagonistic
bacteria inhibit the
growth of </span><em style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">V. cholerae</em><span style="orphans:2;widows:2;text-decoration-style:initial;text-decoration-color:initial;float:none;word-spacing:0px;">. </span></font><span style="font-size:10.0pt;"></span></p>
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<div class="yiv2083492290moz-cite-prefix">On 4/5/2022 10:47 AM, Jonathan Goode
wrote:<br clear="none">
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<div class="yiv2083492290gmail_quote">
<div dir="ltr">
<div class="yiv2083492290gmail_quote">
<div dir="ltr"><span style="font-size:14pt;font-family:New;">(NOTE: Repeated
Reminder with contents unchanged.)<span></span></span>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:14pt;font-family:New;"><span> </span></span></p>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:14pt;font-family:New;">Our Zoom Meeting ID
is 972 6146
0830. Detailed instructions for joining us are at
the end of this message.<span></span></span></p>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:12pt;font-family:New;"><span> </span></span></p>
<table style="width:100%;margin-left:1.5pt;" width="100%" cellspacing="3" cellpadding="0" border="0"><tbody><tr><td colspan="1" rowspan="1" style="width:17.78%;padding:0.75pt;" width="17%">
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><span style="font-size:14pt;font-family:New;">April 6,
2022</span></b><b><span style="font-size:14pt;font-family:New;"><span></span></span></b></p>
</td><td colspan="1" rowspan="1" style="width:81.26%;padding:0.75pt;" width="81%">
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><span style="font-size:14pt;font-family:New;">John Snow
and the Cholera Epidemic of 1854</span></b><span style="font-size:14pt;font-family:New;">, presented
by Jerry Slate<span></span></span></p>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:14pt;">John Snow (1813 –
1858) was a British physician who became
interested in the transmission of cholera.
At the time, airborne transmission of
disease, miasma, was the accepted model
for cholera. When Snow showed his data on
the cholera epidemic of 1854 (in a manner
not previously seen), there was much
resistance in the scientific community to
a paradigm shift.</span></i><b><span style="font-size:14pt;"><span></span></span></b></p>
</td></tr></tbody></table>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><i><span style="font-size:16pt;font-family:New;color:black;">Below
are our plans for Upcoming Meetings. For
more schedule information, please refer to <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://wiki.toku.us/doku.php?id=lctg_speaker_schedule" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://wiki.toku.us/doku.php?id=lctg_speaker_schedule</a>
We will continue to have an online presentation
(almost) every Wednesday until
it is prudent for us to resume meeting in
person.<span></span></span></i></b></p>
<table width="95%" cellspacing="3" cellpadding="0" border="0"><tbody><tr style="min-height:31.05pt;"><td colspan="1" rowspan="1" style="width:18.4%;padding:0.75pt;min-height:31.05pt;" width="18%">
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><span style="font-size:14pt;font-family:New;">April 13,
2022<span></span></span></b></p>
</td><td colspan="1" rowspan="1" style="width:80.62%;padding:0.75pt;min-height:31.05pt;" width="80%">
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:14pt;font-family:New;">Craig Fields
on <b>DARPA</b> (not to be recorded at
speaker's request) </span><span style="font-size:14pt;font-family:New;color:black;">Dr.
Craig I Fields will be coming to the
Computer Group primarily to discuss his role
as Director of DARPA.</span><span style="font-size:14pt;font-family:New;"><span></span></span></p>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:14pt;font-family:New;color:black;">He
received his BS degree from the
Massachusetts Institute of Technology and
his Ph.D. from the Rockefeller University.
He served on the faculty of Harvard
University; he was the Director of the
Defense Advanced Research Projects Agency
(DARPA); he was the Chairman and Chief
Executive Officer of the Microelectronics
and Computer Technology Corporation (MCC).
He is a Member of the Defense Science Board,
joining the Board in 1993 and Chairman of
the Board for 14 years thereafter.</span><span style="font-size:14pt;font-family:New;"><span></span></span></p>
</td></tr><tr style="min-height:31.05pt;"><td colspan="1" rowspan="1" style="width:18.4%;padding:0.75pt;min-height:31.05pt;" width="18%">
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><span style="font-size:14pt;font-family:New;">April 20,
2022<span></span></span></b></p>
</td><td colspan="1" rowspan="1" style="width:80.62%;padding:0.75pt;min-height:31.05pt;" width="80%">
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><span style="font-size:14pt;font-family:New;">Potpourri</span></b><span style="font-size:14pt;font-family:New;"><br clear="none">
<b>Space Update</b> (conclusion) George
Gamota<span></span></span></p>
</td></tr></tbody></table>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><b><i><span style="font-size:12pt;font-family:New;color:black;">SPECIAL
NOTE - </span></i></b><i><span style="font-size:12pt;font-family:New;color:black;">Links
to many of our previous sessions are
available online at <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="http://lctg.toku.us/" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">http://lctg.toku.us/</a>,
thanks to the diligence of Steve Isenberg. This
includes our sessions<span></span></span></i></p>
<ul style="margin-top:0in;margin-bottom:0in;" type="disc"><li style="color:black;margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;">Downdraft
Radar Technology, presented by Dr. Jim Evans. <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://youtu.be/bZpFPjNnNBA" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://youtu.be/bZpFPjNnNBA</a><span></span></span></i></li><li style="color:black;margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;">Quantum
Mechanics, part 1: <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://youtu.be/m1vdpQuUzaw" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://youtu.be/m1vdpQuUzaw</a><span></span></span></i></li><li style="color:black;margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;">Virus Package
Update <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://youtu.be/hw9JEz9GIJE" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://youtu.be/hw9JEz9GIJE</a>
<span></span></span></i></li><li style="color:black;margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;">Lagrangian
Points, especially L2. <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://youtu.be/LNOF_mexw-o" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://youtu.be/LNOF_mexw-o</a>
<span></span></span></i></li></ul>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;color:black;">Virus
Follow-up: Browser
Guards.</span></i> <i><span style="font-size:12pt;font-family:New;color:black;"><a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://youtu.be/Uy9N8rb0zUk" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://youtu.be/Uy9N8rb0zUk</a>
<span></span></span></i></p>
<ul style="margin-top:0in;margin-bottom:0in;" type="disc"><li style="color:black;margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;">Space
Update: <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://youtu.be/NWw-xQM5PxA" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://youtu.be/NWw-xQM5PxA</a>
<span></span></span></i></li><li style="color:rgb(11,83,148);margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><i><span style="font-size:12pt;font-family:New;color:black;">Managing
File Size, special presentation from New Zealand
by our group’s former leader, Allan Sherman <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://www.youtube.com/watch?v=o2V4GAm_YHo" style="color:blue;text-decoration:underline;">https://youtu.be/o2V4GAm_YHo</a><span>
</span></span></i><span style="font-size:12pt;"><span></span></span></li></ul>
<p style="margin:0in 0in 0.0001pt 0.5in;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:12pt;color:rgb(11,83,148);"><span> </span></span></p>
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Lexington
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but note that the URL and phone number shown are
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your browser, go to: <a rel="nofollow noopener noreferrer" shape="rect" target="_blank" href="https://zoom.us/j/97261460830" style="color:blue;text-decoration:underline;" class="yiv2083492290moz-txt-link-freetext">https://zoom.us/j/97261460830</a></span><span style="font-size:14pt;font-family:New;"><span></span></span></li><li style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:14pt;font-family:New;color:black;">>From
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+16468769923,,97261460830</span><span style="font-size:14pt;font-family:New;"><span></span></span></li><li style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:14pt;font-family:New;color:black;">From a
“dumb” telephone, call 1 646 876 9923 and enter
meeting ID: 972 6146 0830 </span><span style="font-size:14pt;font-family:New;"><span></span></span></li></ul>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:12pt;font-family:New;color:black;">Once the
connection is
established, you may need to locate and use the
on-screen controls that turn on
the sound and the video. You should be able to see
and hear others and they
should be able to see and hear you, if you have a
camera and microphone (each
of which you can unmute selectively).</span><span style="font-size:12pt;font-family:New;"><span></span></span></p>
<p style="margin:0in 0in 0.0001pt;font-size:10pt;" class="yiv2083492290MsoNormal"><span style="font-size:12pt;font-family:New;"><span> </span></span></p>
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